In a recent research, led by Dr. Paul Kubes (PhD) Justin Deniset (PhD) and Paul Fedak (MD, PhD), researchers from Calgary University discovered an unidentified cell population in the pericardial fluid found within the sac around the heart that can heal heart. This search can open many pathways for new treatments for heart patients.
In this joint search conducted by the Fedak Cube and kubes Lab, the team of researchers found that a specific cell, GTA 6 + pericardial cavity macrophages, is helpful in repairing the injured heart in rats. This cell was discovered in the pericardial fluid of a rat, whose heart was injured.
In this study, researchers also found that the same cells were also found within the human pericardium of people with injured hearts, which confirms that the repair cells promises of a new therapy for patients who are suffering from heart injury or heart diseases.
Kubes, the Director of the Snyder Institute for Chronic Diseases at the Cumming School of Medicine and Professor in the Department of Physiology and Pharmacology, says about it, “The fuel that powered this study is the funding from the Heart and Stroke Foundation of Canada, the collaboration between two major research institutes at CSM (Snyder and Libin) and the important contribution of philanthropy from the Libin and Snyder families to obtain imaging equipment available to very few programs globally.“
The importance of this research in Cardiac Science is so high because before discovering this possibility, the heart doctors never thought that the cells outside the heart could play an important role in the treatment and repair of the heart after injury. As compared to other organs, the heart has a very limited capacity to heal itself, and this is the reason why the number of people who die from heart disease in the whole world is constantly increasing.
The discovery of this cell spent less than three years, which is a relatively quick deadline to transfer research from the lab and animal models to people, and all this is possible due to the discipline of basic researchers working together and working with heart surgeon and clinician-researcher.
Fedak, a professor in the Department of Cardiac Sciences says, “Our discovery of a new cell that can help heal injured heart muscle will open the door to new therapies and hope for the millions of people who suffer from heart disease. We always knew that the heart sits inside a sac filled with a strange fluid. Now we know that this pericardial fluid is rich with healing cells. These cells may hold the secret to repair and regeneration of new heart muscle. The possibilities for further discovery and innovative new therapies are exciting and important.“
Now ahead of this Fedak has expressed the desire to recruit a basic scientist to move research for a comprehensive study of human heart repairs. This new research program will expand cooperation between basic and clinical research to find potential new treatments to improve heart repair.
Thanks to, the Heart and Stroke Foundation of Canada, the Canadian Institutes of Health Research, the Canada Research Chairs Program, and the National Institutes of Health, who supported this research.
Hopefully, this research will succeed in fulfilling its purpose and soon humans will get benefits of it. Apart from this, if you want to know any other information related to this research or the cell that can heal heart, you can ask us in the comments section.
Source: University of Calgary